Inicio / Investigación / Publicaciones



Artículos científicos


Martinez-Bonet M and MADRID R. A novel single domain in HIV-1 Nef is required for Lck binding, CD4 downregulation and Nef-enhanced optimal infectivity. Submitted to PLos Pathogens.  


Briz V., Serramía MJ., Madrid R., Turrin CO., Caminade AM., Majoral JP., and Muñoz-Fernández M.Á. Validation of a Generation 4 Phosphorus-Containing Polycationic Dendrimer for Gene Delivery against HIV-1. Current Medicinal Chemistry 2012.


Jiménez J.L., Gómez R., Briz V., Madrid R., Bryszews M., de la Mata F.J., and  Muñoz-Fernández M.Á.. Carbosilane dendrimers as carriers of siRNA. J. Drug Deliv. Sci. Tech., 2012.


MADRID R*, Aranda JF, Rodríguez-Fratichelli AE, Ventimiglia, L, Andres-Delgado L, Shehata M, Fanayan S, Gomez S, Jiménez A, Martin-Belmonte F, Byrne JA, and Alonso MA* The formin INF2 regulates basolateral-to-apical transcytosis and lumen formation in association with Cdc42 and MAL2. Developmental Cell. 2010.


Andrés-Delgado A, Antón OM, MADRID R, Byrne, J and Alonso MA.Formin INF2 regulates MAL-mediated transport of Lck to the plasma membrane of human T lymphocytes. Blood 2010.


Py B, Basmaciogullari S, Zarka M, Moura IC, Benhamou M, Monteiro RC, Hocini, H, Bouchet J, MADRID R, and Benichou S. The phospholipid scramblases 1 and 4 are cellular receptors for the secretory leukocyte protease inhibitor and interact with CD4 at the plasma membrane. PLos ONE. 2009.


Hannemann, S, MADRID, R, Stastna, J, Kitzing, T, Gasteier, J, Schönichen, A, Bouchet, J, Jimenez, A, Geyer, M, Grosse, R, Benichou, S and Fackler O T. The Diaphanous Related Formin FHOD1 Associates with ROCK1 and Promotes Src-dependent Plasma Membrane Blebbing J.Biol. Chem. 2008.


Coleman, SH, MADRID, R, Van Damme, N, Mitchell, RS, Bouchet, J, Servant, C, Pillai, S, Benichou, S, and Guatelli, JC. Modulation of Cellular Protein Trafficking by Human Immunodeficiency Virus Type- 1 Nef: Role of the Acidic Residue in the ExxxLL Motif. Virology  2006.



Gasteier JE, Schroeder S, Muranyi W, MADRID R, Benichou S, and Fackler OT. FHOD1 Coordinates Actin Filament and Microtubule Alignment to Mediate Cell Elongation. Exp. Cell Res. 2005.


MADRID R, Gasteier JE, Bouchet J, Schroder S, Geyer M, Benichou S, and Fackler OT. Oligomerization of the Diaphanous-Related Formin FHOD1 Requires a Coiled-coil Motif Critical for its Cytoskeletal and Transcriptional Activities. FEBS Lett. 2005.


MADRID R, Janvier K, Hitchin D, Day J, Coleman S, Noviello C, Bouchet J, Benmerah A, Guatelli J, Benichou S. Nef-induced Alteration of the Early/Recycling Endosomal Compartment Correlates with Enhancement of HIV-1 Infectivity. J Biol Chem. 2005.


Coleman SH, Van Damme N, Day JR, Noviello CM, Hitchin D, MADRID R, Benichou S, and Guatelli JC. Leucine-Specific, Functional Interactions Between Human Immunodeficiency Virus Type 1 Nef and Adaptor Protein Complexes. J Virol. 2005.


Gasteier JE, MADRID R, Krautkramer E, Schroder S, Muranyi W, Benichou S, and Fackler OT. Activation of the Rac-Binding Partner FHOD1 Induces actin Stress Fibers via a ROCK-Dependent Mechanism. J Biol Chem. 2003.


Janvier K, Craig H, Hitchin D, MADRID R, Sol-Foulon N, Renault L, Cherfils J, Cassel D, Benichou S and Guatelli J. HIV-1 Nef Stabilizes the Association of Adaptor Protein Complexes type 1 and 3 with Membranes. J. Biol. Chem. 2003.


MADRID R, Le Maout S, Barrault MB, Janvier K, Benichou, S. and Mérot J.Polarized Trafficking and Surface Expression of the AQP4 Water Channel are Coordinated by Serial and Regulated Interactions with Different Clathrin-Adaptor Complexes. EMBO J.2001.


MADRID R*, Bañuelos MA*, and Rodriguez-Navarro A. Individual functions of the HAK and TRK potassium transporters of Schwanniomyces occidentalis. Mol. Microbiol, 2000.


MADRID R, Le Maout S, Barrault MB. and Mérot J. Two distinct signals determine the basolateral targeting of AQP4 in the renal epithelial cell line MDCK. Molecular Biology and Physiology of water and Solute Transport. (Hohmann, S and Nielsen S, eds) pp.159-165. Kluwer Academic/Plenun Publishers.2000.


 MADRID R, Gómez MJ, Ramos J. and Rodriguez‑Navarro A. Ectopic potassium uptake in trk1trk2 mutants of Saccharomyces cerevisiae correlates with a hyperpolaryzed plasma membrane. J. Biol. Chem. 1998.


Patentes y modelos de utilidad


Benichou S., Py B.,Basmaciogullari S., Bouchet J, Deprez B, and Madrid R. Inhibidores del complejo Escramblasa/CD4 para el tratamiento de infecciones por Lentivirus. BIO 06036 – BENICHOU. INSERM (FRANCIA)



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